{"id":8344,"date":"2020-10-08T17:11:27","date_gmt":"2020-10-08T12:11:27","guid":{"rendered":"https:\/\/spinalcordinjuryzone.com\/?p=54562"},"modified":"2020-10-08T17:11:27","modified_gmt":"2020-10-08T12:11:27","slug":"scar-free-healing-after-spinal-cord-injury-relies-on-specialized-cells","status":"publish","type":"post","link":"https:\/\/wheelchair-experts.in\/scar-free-healing-after-spinal-cord-injury-relies-on-specialized-cells\/","title":{"rendered":"Scar-free healing after spinal cord injury relies on specialized cells"},"content":{"rendered":"<p><!-- content --><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignright size-thumbnail wp-image-54566\" src=\"https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/neuron-2-150x150.jpg\" alt width=\"150\" height=\"150\">One of the reasons people rarely recover from spinal cord injury is the scar tissue that develops, preventing nerve cells from reconnecting. But a new study from <a target=\"_blank\" href=\"http:\/\/www.childrenshospital.org\/research\/researchers\/h\/zhigang-he\" rel=\"noreferrer noopener\">Zhigang He, PhD<\/a>, of the <a target=\"_blank\" href=\"https:\/\/kirbyneuro.org\/\" rel=\"noreferrer noopener\">F.M. Kirby Neurobiology Center<\/a> at Boston Children\u2019s Hospital, demonstrated a way to minimize scar cell formation in adult mice after a spinal cord injury. <a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41586-020-2795-6\" rel=\"noreferrer noopener\">The study,<\/a> published in <em>Nature,<\/em> offers insights for new approaches to treating spinal cord injuries.<span id=\"more-54562\"><\/span><\/p>\n<h2>Key Takeaways<\/h2>\n<p>Scar tissue prevents nerves from communicating with each other.<\/p>\n<p>Microglia cells in the central nervous system help prevent scar tissue formation after spinal cord injuries in newborn mice.<\/p>\n<p>Transplanted newborn microglia cells drastically reduced scar formation in adult mice with spinal cord injury, opening the door to new treatment possibilities.<\/p>\n<figure id=\"attachment_54564\" aria-describedby=\"caption-attachment-54564\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-54564\" src=\"https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/scar-free.jpg\" alt width=\"800\" height=\"533\" srcset=\"https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/scar-free.jpg 800w, https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/scar-free-300x200.jpg 300w, https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/scar-free-768x512.jpg 768w, https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/scar-free-696x464.jpg 696w\" sizes=\"(max-width: 800px) 100vw, 800px\"><figcaption id=\"caption-attachment-54564\" class=\"wp-caption-text\">Researchers have discovered that microglia cells found in the central nervous system help prevent scars during healing. (Image: Adobe Stock\/Illustration: Sebastian Stankiewicz, Boston Children\u2019s)<\/figcaption><\/figure>\n<h2>Scar tissue prevents nerve cell reconnections<\/h2>\n<p>Some animals, like fish and amphibians, easily heal a spinal cord injury without development of scar tissue. Instead, the axons of their nerve cells quickly regrow, re-establishing connections. Axons are the long fibers that extend from a nerve cell to connect with surrounding nerve cells.<\/p>\n<p>However, this is not true in adult mammals. Axons do not regrow after spinal cord injury. Also, many types of harmful cells accumulate around the injury site further interfering with the axons ability to reconnect and transmit signals between nerve cells.<\/p>\n<figure id=\"attachment_54566\" aria-describedby=\"caption-attachment-54566\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-54566\" src=\"https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/neuron-2.jpg\" alt width=\"800\" height=\"533\" srcset=\"https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/neuron-2.jpg 800w, https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/neuron-2-300x200.jpg 300w, https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/neuron-2-768x512.jpg 768w, https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/neuron-2-696x464.jpg 696w\" sizes=\"(max-width: 800px) 100vw, 800px\"><figcaption id=\"caption-attachment-54566\" class=\"wp-caption-text\">After a spinal cord injury, axons that promote communication between nerve cells are damaged. (Image: Adobe Stock\/Illustration: Sebastian Stankiewicz, Boston Children\u2019s)<\/figcaption><\/figure>\n<h2>Specialized cells clean up after injury<\/h2>\n<p>In this paper, He found that microglia cells \u2014 a type of immune cell found in the brain and spinal cord that remove damaged nerve cells and infection\u2014 have an essential protective role in scar-free wound repair.<\/p>\n<figure id=\"attachment_54565\" aria-describedby=\"caption-attachment-54565\" class=\"wp-caption alignright\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-54565\" src=\"https:\/\/spinalcordinjuryzone.com\/wp-content\/media\/He-Zhigang.jpg\" alt width=\"132\" height=\"170\"><figcaption id=\"caption-attachment-54565\" class=\"wp-caption-text\">Zhigang He<\/figcaption><\/figure>\n<p>To learn more, He\u2019s team studied spinal cord injury and repair responses in 2-day-old mice.<\/p>\n<p>\u201cUnexpectedly, we found that the injury in these young pups lead to scar-free healing that permitted the growth of axons through the site of the lesion,\u201d says He.<\/p>\n<p>When they studied a type of mouse that did not have normal numbers of microglia, they found that this scar-free healing did not occur, nor did axon regrowth.<\/p>\n<p>\u201cThis means that the microglia have a critical role in orchestrating the injury response,\u201d says He.<\/p>\n<h2>Protein inhibitors part of the scar-free healing response<\/h2>\n<p>The team learned that microglia have at least two roles in scar-free healing. First, they help re-form bridges between the severed axon ends. Second, microglia cells from newborn mice \u2014 but not adult mice \u2014 produce a number of molecules that interfere with the action of certain harmful proteins.<\/p>\n<p>\u201cThese protein inhibitors are involved in quickly tamping down the inflammatory response after spinal cord injury,\u201d says He. \u201cThe microglia essentially orchestrated swift removal of harmful cell debris after injury and stopped inflammation.\u201d<\/p>\n<blockquote readability=\"7\">\n<p>\u201cTogether, the findings point to potential strategies to facilitate scar-free healing after spinal cord injury.\u201d \u2013 Zhigang He<\/p>\n<\/blockquote>\n<p>The team next tested whether axons could be regenerated in adult mice with spinal cord injuries. In a series of experiments, they found transplantation of adult microglia cells, pre-treated with protein inhibitors, significantly improved healing and axon regrowth. Results were similar when newborn microglia were transplanted into adult mice with spinal cord lesions.<\/p>\n<p>\u201cWith these results we are convinced that microglia is a primary organizer for this scar-free wound healing,\u201d says He.<\/p>\n<h2>A new path for spinal cord treatments and neurodegenerative disease<\/h2>\n<p>\u201cTogether, the findings point to potential strategies to facilitate scar-free healing after spinal cord injury,\u201d says He.<\/p>\n<p>The team is now testing several types of protein inhibitors to see which may be most effective in boosting the scar-free healing potential of microglia cells.<\/p>\n<p>This discovery may also help understanding of treatments for neurodegeneration in general, such as in Alzheimer\u2019s disease, ALS, and Parkinson\u2019s disease<\/p>\n<p>\u201cOne of the key players in these diseases is microglia,\u201d says He. His laboratory is now studying the role dysfunctional microglia may have in the ongoing destructive nerve damage seen in these diseases. \u201cPerhaps we can find a gene that might convert those chronically active microglia to treat neurodegeneration.\u201d<\/p>\n<p>by Alice McCarthy<\/p>\n<p class=\"wp-block-gutenberg-boilerplate-es5-cta cta\"><strong>Read more about <a target=\"_blank\" href=\"https:\/\/discoveries.childrenshospital.org\/spinal-cord-injury\/\" rel=\"noreferrer noopener\">spinal cord injury research<\/a> at Boston Children\u2019s.<\/strong><\/p>\n<p> <!-- A generated by theme --> <!-- end A --> ** This post was originally published on https:\/\/spinalcordinjuryzone.com\/news\/54562\/scar-free-healing-after-spinal-cord-injury-relies-on-specialized-cells<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the reasons people rarely recover from spinal cord injury is the scar tissue that develops, preventing nerve cells from reconnecting. But a new study from Zhigang He, PhD,<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[264,267],"tags":[319,318,317],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Scar-free healing after spinal cord injury relies on specialized cells &#187; : Wheelchair Experts\u00ae (Buy Wheelchairs Online in India)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wheelchair-experts.in\/scar-free-healing-after-spinal-cord-injury-relies-on-specialized-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scar-free healing after spinal cord injury relies on specialized cells &#187; : Wheelchair Experts\u00ae (Buy Wheelchairs Online in India)\" \/>\n<meta property=\"og:description\" content=\"One of the reasons people rarely recover from spinal cord injury is the scar tissue that develops, preventing nerve cells from reconnecting. 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